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Albendazole 2500mg

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COMPOSITION:
Contains per bolus: 
Albendazole............................................... 2500mg
Carrier ad....................................................16g

DESCRIPTION:
Albendazole is a synthetic anthelmintic which belongs to the group of benzimidazole-derivatives with activity against a broad range of worms and at a higher dosage level also against adult stages of liver fluke.

PHARMACOLOGICAL ACTION:
Albendazole combined with eelworm's microtubule protein and play a role. After albenzene combined with β-tubulin, it can prevent dimerization between albenzene and α-tubulin assembling into microtubules. Microtubules are the basic structure of the many cell units. Albendazole's affinity to nematodes tubulin is significantly higher than the affinity of mammalian tubulin, so toxicity to mammalian is small.

INDICATIONS:
Prophylaxis and treatment of worminfections in calves and cattle like: 
Gastrointestinal worms: Bunostomum, Cooperia, Chabertia, Haemonchus, Nematodirus, Oesophagostomum, Ostertagia, Strongyloides, and Trichostrongylus spp.
Lung worms: Dictyocaulus viviparus and D. filaria.
Tapeworms: Monieza spp.
Liver-fluke: adult Fasciola hepatica.
Albendazole has also an ovicidal effect.

CONTRA-INDICATIONS:
Administration in the first 45 days of gestation.

SIDE EFFECTS:
Hypersensitivity reactions.

DOSAGE AND ADMINISTRATION:
For oral administration. 
For roundworms and tapeworms:
Cattle/buffalo/horses/sheep/goats: 5mg/kg bodyweight
Dogs/cats: 10 to 25mg/kg bodyweight
For flukes:
Cattle/buffalo: 10mg/kg bodyweight
Sheep/goats: 7.5mg/kg bodyweight 
Calves and cattle: 1 bolus per 300 kg. body weight.
For liver-fluke: 
1 bolus per 250 kg. body weight.

WITHDRAWAL TIME:
- For meat: 12 days.
- For milk: 4 days.

WARNING:
Keep out of reach of children.

STORAGE:
Store in tightly cool, dry place protected from light.

VALIDATION PERIOD:
3 years.

PACKING:
5 bolus per blister (10 blister per box)